What are the structural characteristics of fermenter products?

1. Online CIP cleaning and SIP disinfection (121°C/0.1MPa).

2. It is designed according to the requirements of sanitary level, with humanized structure design and convenient operation. Smooth transmission, low noise.

3. Suitable for diameter to height ratio design, customized stirring device, energy saving, stirring, fermentation effect is good.

4. Mirror polishing treatment of inner tank surface (roughness)Ra≤0.4µm; Import and export, sight mirror, manhole, inner tank welding using tensile turning process arc transition, smooth and easy to clean, no dead Angle, to ensure the reliability, stability and consistency of the production process "cGMP" and so on.

First, the fermenter tank pre-cleaning method

1. Release materials after each batch of fermentation. Carefully remove pH and DO electrodes and rinse with running water. Standard Operating Procedures for maintenance of pilot pH electrodes and standard Operating procedures for pilot dissolved oxygen electrodes.

2. Rinse the electrode jack with a small amount of tap water on the pH and DO of the tank, and then use the matching piston plug and tighten it with the screw cap. And record the operation content.

3. When cleaning the jar below 50L, loosen the top cap screw and each connection, remove the top cap of the fermenter, remove the inoculation cap, supplementary hole plug, defoaming agent probe and reserved hole plug, clean and wipe each part with a rag, and then rinse with running water. Clean the lid, the interface between the lid and the tank, the inside of the tank and the seal of the blender with a soft brush, rinse the residue with running water, and collect the rinse water in a bucket. Check the ring, clean it with a rag (if there is any aging, replace and record in time), then equip the parts in turn, cover the fermenter, tighten the fixing screws symmetrically, and check the sealing performance by air compression. If there is leakage, relieve the pressure in time, and check the leakage for treatment and solution. And record the operation content.

4. The feeding cover, inoculation cap, filling hole plug, defoaming agent probe and each reserved hole plug should be loosened for the cleaning of the tank body above 50L. Each part should be cleaned with a rag and cleaned with tap water. Turn on the power lamp, check whether there are large slag and other sundries on the inner wall of the tank, if there are, use special tools to remove sundries. Brush the inner wall with a soft brush, the lid interfaces with the tank, the inner wall of the tank is sealed with the blender, rinse the residue and residue with running water, and collect the rinse water in a bucket. Check the ring and clean it (if there is aging, replace it in time), then equip the parts in turn, and check the sealing performance through air pressure preservation. If there is leakage, relieve pressure in time, check the leakage for treatment and solution. And record the operation content.

Two, fermenter application conditions and scope

A fermenter is a device for mechanically stirring and fermenting materials. The device adopts internal circulation mode and uses stirring paddle to disperse broken bubbles, which has high oxygen dissolution rate and good mixing effect. The tank is made of SUS304 or 316L imported stainless steel. The tank is equipped with automatic spray cleaning machine head to ensure that the production process meets the GMP requirements.

Fermenter refers to an industrial device used to carry out microbial fermentation. Its main body is generally made of stainless steel plate main cylinder, its volume in 1m3 to hundreds of m3. In the design and processing should pay attention to the structure is tight and reasonable. Can withstand steam sterilization, with appropriate operating flexibility, minimize the internal accessories (avoid dead corners), has strong material and energy transfer performance, can be properly adjusted cleaning, reduce pollution, suitable for the production of various products, reduce energy consumption.

The structure of the fermenter for anaerobic fermentation (e.g. production of alcohol, solvents) can be relatively simple. The fermenter used for good gas fermentation (such as the production of antibiotics, amino acids, organic acids, vitamins, etc.) needs to continuously inject a large amount of sterile air into the tank, and to consider the utilization rate of the air into the tank, so the structure of the fermenter is more complex, commonly used are mechanical stirring fermenter, bubbling fermenter and rising fermenter.

Fermenter is widely used in dairy products, beverages, biological engineering, pharmaceutical, fine chemical and other industries. The tank body is equipped with sandwich and insulation layer, which can be heated, cooled and kept warm. The tank body and the upper and lower filling head (or cone) are processed by rotating R Angle, and the inner wall of the tank is polished by mirror without sanitary dead Angle. The fully enclosed design ensures that the material is always in the environmental protection mixed fermentation state. The equipment is equipped with air breathing hole, CIP cleaning nozzle, manhole and other devices.